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Intraoperative cardiac arrest caused by unexpected vasospastic angina requiring prolonged resuscitation using extracorporeal membrane oxygenation: a case report



Vasospastic angina (VSA) occurring during surgery is rare but can lead to sudden intraoperative cardiac arrest.

Case presentation

A 77-year-old man with hypertension, and no history of coronary artery disease, displayed an abrupt ST-segment elevation on the electrocardiogram (ECG) during laparoscopic inguinal hernia surgery under general anesthesia. Subsequently, ventricular fibrillation (VF) occurred, with a finding suggesting ischemic myocardial contracture by transesophageal echocardiography. VF was refractory to cardiopulmonary resuscitation (CPR), and veno-arterial extracorporeal membrane oxygenation (VA ECMO) was introduced. Spontaneous circulation resumed 77 min post-cardiac arrest. VSA was confirmed through the patient’s clinical course and coronary angiography. Subsequently, VA ECMO was terminated, and the patient was discharged uneventfully.


Extracorporeal CPR may be a valuable alternative to extended resuscitation for refractory ventricular arrhythmias by VSA.


Vasospastic angina (VSA) arises when a coronary artery vasospasm leads to a decreased blood supply to the myocardium [1]. It is typified by heart attacks that transpire at rest, especially during nighttime and early mornings. However, it can also manifest intraoperatively. A prior study indicated that 18 out of 42 patients, who underwent coronary catheterization due to intraoperative cardiovascular events among a total of 77,745 patients undergoing non-cardiac surgeries, were diagnosed with VSA [2]. In certain scenarios, VSA might culminate in cardiac arrest, making its management during resuscitation challenging [3].

Extracorporeal CPR (ECPR), a resuscitation approach employing extracorporeal membrane oxygenation, is contemplated when standard resuscitation proves ineffective [4,5,6,7,8]. Even though intraoperative cardiac arrest occurrences are exceedingly rare, ECPR can be a therapeutic recourse.

In this paper, we detail a case of an intraoperative cardiac arrest instigated by an unforeseen VSA that necessitated extended resuscitation via ECPR. We also illustrate the variation in the depth of anesthesia values during resuscitation and deliberate on both the quality of resuscitation and the prognostic implications.

Case presentation

A 77-year-old male, measuring 170 cm and weighing 64.7 kg, was slated for a laparoscopic inguinal hernia operation under general anesthesia, complemented with a peripheral nerve block. His medical history included hypertension, and he was on amlodipine and candesartan. He consumed alcohol minimally and had a smoking history of 10 cigarettes per day from the age of 20 to 30. Preoperative 12-lead electrocardiogram (ECG) showed a first-degree atrioventricular node block and left axis deviation (Fig. 1). The preoperative revised cardiac risk index was scored at 0 out of a possible 6 points [9].

Fig. 1
figure 1

Preoperative electrocardiogram

Anesthesia was induced with 100 mg propofol, 150 μg fentanyl, 0.3 μg/kg/min remifentanil, and 60 mg rocuronium and maintained with 1 L/min oxygen, 2 L/min air, 1.5% sevoflurane, and 0.1−0.2 μg/kg/min remifentanil. Additionally, 100 μg bolus fentanyl and 10 mg rocuronium were administered as needed. The SEDLINE® system (Masimo Corporation; Irvine, CA, USA) was used to monitor the depth of anesthesia, ensuring the patient state index (PSi) remained between 25 and 50. A standard 3-lead ECG was continually monitored. Prior to the surgery, an ultrasound-guided rectus sheath block was administered with 50 mL of 0.125% levobupivacaine. Ephedrine, in 4 or 8 mg boluses, was administered as needed for intraoperative hypotension.

The surgery proceeded without complications. Immediately before completing mesh fixation, a sudden ST elevation appeared on the ECG, with a heart rate of 46 bpm, blood pressure of 102/50 mmHg, peripheral oxygen saturation of 98%, end-tidal carbon dioxide tension (EtCO2) of 40 mmHg, and PSi of 35. After 110 s, ventricular fibrillation (VF) manifested on the ECG, leading to cardiac arrest (Fig. 2). The attending anesthesiologist swiftly notified the available physicians. The laparoscopic procedure was halted, all anesthetic agents were discontinued, and cardiopulmonary resuscitation (CPR) was initiated immediately based on the Advanced Cardiovascular Life Support algorithm. Despite four attempts at defibrillation, the VF persisted. Transesophageal echocardiography detected no significant anomalies except for ischemic myocardial contracture. Given the patient’s non-response to 150 mg of amiodarone and ongoing CPR, extracorporeal CPR (ECPR) was initiated for this refractory lethal arrhythmia.

Fig. 2
figure 2

Electrocardiogram (ECG) during surgery. Initial ECG shows no abnormalities a The ST segment elevated, followed by the emergence of ventricular fibrillation after 110 s b Spontaneous circulation returned 77 min post-cardiac arrest c

Veno-arterial extracorporeal membrane oxygenation (VA ECMO) was initiated 58 min post-cardiac arrest. Return of spontaneous circulation was achieved 77 min post-arrest after the fifth defibrillation attempt. In total, 18 mg of adrenaline was administered. During CPR, along with ECG, non-invasive blood pressure, arterial blood pressure, EtCO2, and PSi were consistently monitored. Arterial blood samples were collected for gas analysis. The EtCO2 was approximately 2–24 mmHg, while the PSi values ranged from 15 to 38, spiking to 50 post-VA ECMO initiation (Fig. 3).

Fig. 3
figure 3

Parameter fluctuations during resuscitation. Following an abrupt ST-T wave elevation, the electrocardiogram indicated ventricular fibrillation leading to cardiac arrest a The laparoscopic procedure and general anesthesia were halted, and standard cardiopulmonary resuscitation was initiated b The patient state index (PSi) value was elevated after the commencement of veno-arterial extracorporeal membrane oxygenation c Spontaneous circulation was restored 77 min post-cardiac arrest upon the fifth defibrillation attempt d Resumption of anesthetic agents resulted in a decline in the PSi value e ABP, arterial blood pressure

Coronary angiography after resuscitation in the angiography room displayed no significant coronary artery stenosis (Fig. 4), leading to a diagnosis of VSA, along with the clinical course. The patient was returned to the operating room, and the surgery was completed under ECMO management. No arrhythmia was observed under continuous administration of amiodarone 50 mg/h and diltiazem 1 μg/kg/min.

Fig. 4
figure 4

Post-resuscitation coronary arteriography. Both the left a and right b coronary arteries showed no significant stenosis

After the operation, the patient was admitted to the intensive care unit. A thorough trans-thoracic echocardiography was performed but no abnormal finding including ischemic regional wall motion abnormality was observed. Targeted temperature management (TTM) was performed to set at 35–36 °C [10, 11]. A brain computed tomography scan revealed no discernible damage from the prolonged resuscitation. ECMO support was ceased a day post-surgery, with TTM continued for 72 h. Consciousness was reestablished, and the patient was relocated to the general ward 8 days after surgery. Oral diltiazem 100 mg/day was initiated as treatment for VSA.

No subsequent residual central nervous system (CNS) symptoms, new arrhythmias, or ECG changes were noted. The consideration was given to implant an implantable cardioverter-defibrillator based on treatment guidelines [12]. Nonetheless, the patient was discharged 28 days post-surgery, choosing against the procedure, given that the incident occurred under general anesthesia. At the 1-year follow-up, he displayed no arrhythmia-related events or apparent CNS symptoms.


We present a case of intraoperative cardiac arrest attributable to VSA, which was successfully resuscitated using ECMO. VSA is associated with several risk factors, such as smoking, alcohol consumption, abnormal lipid metabolism, stress, and inflammation. However, predicting VSA remains challenging [1, 13]. Numerous cardiac risk assessments for noncardiac surgery have been proposed. For example, the revised cardiac risk index, a frequently utilized scoring system with 6 criteria, indicates that scores of 0 or 1 are associated with a perioperative cardiovascular event rate of 0.4% or 0.9%, respectively, while a score of 3 points corresponds to an event rate of 6.6% [9]. Notably, VSA can occur even in patients with low scores [2]. From the perspective of intraoperative risk factors, anesthetic agents and hypertensive medications, such as phenylephrine and ephedrine, have been implicated in VSA onset [14, 15]. Moreover, Koshiba et al. observed that factors like inadequate anesthesia depth, vasopressor use, vagal reflexes, and epidural blocks were potential triggers [16]. In the case discussed, VSA signs did not immediately follow hypotensive episodes or ephedrine administration, and no other discernible triggers were identified. In terms of treatment, agents like nitroglycerin and calcium channel blockers might have been beneficial. Furthermore, nitroglycerine can serve as a diagnostic therapeutic tool [17]. We were unable to prevent the cardiac arrest because of the swift progression of symptoms. This underscores the importance of suspecting VSA during intraoperative sudden ST elevations occurs in patients without discernible triggers or histories to ensure timely intervention.

Literature offers varying prognosis accounts concerning intraoperative cardiac arrests [18, 19]. While prompt identification and CPR are crucial, performing CPR on anesthetized patients presents challenges. As per guidelines on managing intraoperative cardiac arrests, ECPR becomes a consideration in refractory cases [20,21,22]. Given potential complications with ECMO, such as bleeding, its indication mandates careful consideration [8, 23]. Yet, when risks are minimized, ECMO can be therapeutically invaluable.

Studies suggest that ECPR is expected to improve low-flow time [24, 25]. Notably, in our case, PSi was elevated after the initiation of ECMO, hinting at better cerebral perfusion. PSi, calculated from a simultaneous four-channel electroencephalography derivation, is typically used during general anesthesia [26, 27]. While correlations between anesthesia depth and postoperative neurologic outcomes have been previously reported, the role of neurological monitoring during resuscitation in clinical settings remains controversial [28]. As this is a single case report, the findings might have limitations. Larger observational studies might be needed to validate the efficacy of monitoring anesthesia depth during resuscitation.

In conclusion, intraoperative VSA can lead to refractory lethal arrhythmias. While anticipating such incidents in patients with no prior history remains challenging, clinicians should be vigilant about VSA as a potential cause of intraoperative cardiac arrest. In select cases, ECPR might offer an advantageous approach over extended resuscitation.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.



Vasospastic angina




Ventricular fibrillation


Cardiopulmonary resuscitation


Extracorporeal cardiopulmonary resuscitation


Veno-arterial extracorporeal membrane oxygenation


Patient state index

EtCO2 :

End-tidal CO2


Targeted temperature management


Central nervous system


  1. He Z, Xu X, Zhao Q, Ding H, Wang DW. Vasospastic angina: past, present, and future. Pharmacol Ther. 2023;249: 108500.

    Article  CAS  PubMed  Google Scholar 

  2. Nagayoshi Y, Kawano H, Kojima S, Soejima H, Kaikita K, Nakayama M, et al. Significance of coronary vasospasm in the perioperative management of non-cardiac surgery. Circ J. 2012;76:1965–71.

    Article  PubMed  Google Scholar 

  3. Nakamura M, Takeshita A, Nose Y. Clinical characteristics associated with myocardial infarction, arrhythmias, and sudden death in patients with vasospastic angina. Circulation. 1987;75:1110–6.

    Article  CAS  PubMed  Google Scholar 

  4. Abrams D, Maclaren G, Lorusso R, Price S, Yannopoulos D, Vercaemst L, et al. Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications. Intensive Care Med. 2022;48:1–15.

    Article  PubMed  Google Scholar 

  5. Suverein MM, Delnoij TSR, Lorusso R, Brandon Bravo Bruinsma GJ, Otterspoor L, Elzo Kraemer CV, et al. Early extracorporeal CPR for refractory out-of-hospital cardiac arrest. N Eng J Med. 2023;388:299–309.

    Article  Google Scholar 

  6. Belohlavek J, Smalcova J, Rob D, Franek O, Smid O, Pokorna M, et al. Effect of intra-arrest transport, extracorporeal cardiopulmonary resuscitation, and immediate invasive assessment and treatment on functional neurologic outcome in refractory out-of-hospital cardiac arrest. JAMA. 2022;327:737.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Yannopoulos D, Bartos J, Raveendran G, Walser E, Connett J, Murray TA, et al. Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation : a phase 2, single centre, open-label, randomised controlled trial. Lancet. 2020;396:1807–16.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Inoue A, Hifumi T, Sakamoto T, Okamoto H, Kunikata J, Yokoi H, et al. Extracorporeal cardiopulmonary resuscitation in adult patients with out-of-hospital cardiac arrest: a retrospective large cohort multicenter study in Japan. Crit Care. 2022;26:129.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Lee TH, Marcantonio ER, Mangione CM, Thomas EJ, Polanczyk CA, Cook EF, et al. Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery. Circulation. 1999;100:1043–9.

    Article  CAS  PubMed  Google Scholar 

  10. Constant AL, Mongardon N, Morelot Q, Pichon N, Grimaldi D, Bordenave L, et al. Targeted temperature management after intraoperative cardiac arrest: a multicenter retrospective study. Intensive Care Med. 2017;43:485–95.

    Article  PubMed  Google Scholar 

  11. Watanabe M, Matsuyama T, Miyamoto Y, Kitamura T, Komukai S, Ohta B. The impact of different targeted temperatures on out-of-hospital cardiac arrest outcomes in patients receiving extracorporeal membrane oxygenation: a nationwide cohort study. Crit Care. 2022;26(1):1–9.

    Article  Google Scholar 

  12. Al-Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB, et al. AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary. Circulation. 2017;2018:138.

    Google Scholar 

  13. Jewulski J, Khanal S, Dahal K. Coronary vasospasm: a narrative review. World J Cardiol. 2021;13:456–63.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Ornek E, Ornek D, Murat SN, Turfan M. Angiographic documentation of coronary artery spasm induced by anesthesia. J Anesth. 2010;24:452–5.

    Article  PubMed  Google Scholar 

  15. Kishimoto N, Kato M, Nakanishi Y, Hasegawa A, Momota Y. Recurrent coronary artery spasm induced by vasopressors during two operations in the same patient under general anesthesia. Anesth Prog. 2018;65:44–9.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Koshiba K, Hoka S. Clinical characteristics of perioperative coronary spasm: reviews of 115 case reports in Japan. J Anesth. 2001;15:93–9.

    Article  CAS  PubMed  Google Scholar 

  17. Beltrame JF, Crea F, Kaski JC, Ogawa H, Ong P, Sechtem U, et al. The who, what, why, when, how and where of vasospastic angina. Circ J. 2016;80:289–98.

    Article  PubMed  Google Scholar 

  18. Hur M, Lee HC, Lee KH, Kim JT, Jung CW, Park HP. The incidence and characteristics of 3-month mortality after intraoperative cardiac arrest in adults. Acta Anaesthesiol Scand. 2017;61:1095–104.

    Article  CAS  PubMed  Google Scholar 

  19. Vane MF, Carmona MJC, Pereira SM, Kern KB, Timerman S, Perez G, et al. Predictors and their prognostic value for no ROSC and mortality after a non-cardiac surgery intraoperative cardiac arrest: a retrospective cohort study. Sci Rep. 2019;9:14975.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Practical Guide for Intraoperative Cardiac Arrest. Accessed.

  21. Moitra VK, Einav S, Thies KC, Nunnally ME, Gabrielli A, Maccioli GA, et al. Cardiac arrest in the operating room: resuscitation and management for the anesthesiologist: part 1. Anesth Analg. 2018;126:876–88.

    Article  PubMed  Google Scholar 

  22. Bartos JA, Grunau B, Carlson C, Duval S, Ripeckyj A, Kalra R, et al. Improved survival with extracorporeal cardiopulmonary resuscitation despite progressive metabolic derangement associated with prolonged resuscitation. Circulation. 2020;141:877–86.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Nguyen ML, Gause E, Mills B, Tonna JE, Alvey H, Saczkowski R, et al. Traumatic and hemorrhagic complications after extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest. Resuscitation. 2020;157:225–9.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Wengenmayer T, Rombach S, Ramshorn F, Biever P, Bode C, Duerschmied D, et al. Influence of low-flow time on survival after extracorporeal cardiopulmonary resuscitation (eCPR). Crit Care. 2017;21(1):157.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Murakami N, Kokubu N, Nagano N, Nishida J, Nishikawa R, Nakata J, et al. Prognostic impact of no-flow time on 30-day neurological outcomes in patients with out-of-hospital cardiac arrest who received extracorporeal cardiopulmonary resuscitation. Circ J. 2020;84:1097–104.

    Article  PubMed  Google Scholar 

  26. Lee KH, Kim YH, Sung YJ, Oh MK. The Patient State Index is well balanced for propofol sedation. Hippokratia. 2015;19:235–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Shirozu K, Nobukuni K, Tsumura S, Imura K, Nakashima K, Takamori S, et al. Neurological sedative indicators during general anesthesia with remimazolam. J Anesth. 2022;36(2):194–200.

    Article  PubMed  Google Scholar 

  28. Roberti E, Chiarini G, Latronico N, Adami EC, Plotti C, Bonetta E, et al. Electroencephalographic monitoring of brain activity during cardiac arrest: a narrative review. Intensive Care Med Exp. 2023;11(1):4.

    Article  PubMed  PubMed Central  Google Scholar 

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We would like to thank the members of Nippon Medical School Musashi-kosugi Hospital. We also would like to thank Editage ( for English language editing.


This study was not supported by any funding.

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All authors contributed to the study conception and design. The project was administered by AS. Material preparation, data collection, and analysis were performed by SS, MO, and FH. The first draft of the manuscript was written by SS and MO, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Shinji Sugita.

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The need for ethics approval was waived by the ethics committee of Nippon Medical School due to the nature of the case report, and the form of an opt-out option (guarantee of information disclosure and opportunity to refuse) was provided on our institution’s website.

The report was performed in accordance with the government ethical guidelines and regulations based on the Declaration of Helsinki.

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The patient provided informed consent for the publication of this report.

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Sugita, S., Obata, M., Hasunuma, F. et al. Intraoperative cardiac arrest caused by unexpected vasospastic angina requiring prolonged resuscitation using extracorporeal membrane oxygenation: a case report. JA Clin Rep 9, 77 (2023).

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