Skip to main content
  • Letter to the Editor
  • Open access
  • Published:

Ultrasound imaging with an electric stimulant was useful in pulsed radiofrequency for chronic knee pain in the medial region

To the Editor

Several studies have reported the successful palliation of knee osteoarthritis-associated chronic pain using pulsed radiofrequency (PRF) targeting of the genicular or saphenous nerve [1, 2]. Ultrasound-guided interventional treatment of these peripheral nerves usually requires identification of landmarks such as bony structures, soft tissue, and vessels, because these peripheral branches are barely identifiable [3, 4]. Moreover, the peripheral branches responsible for chronic knee pain are difficult to identify the genicular branch of the tibial nerve or the peripheral branches of the saphenous nerve [5]. In this case, we successfully identified the infrapatellar branch of the saphenous nerve as the cause of chronic knee pain in the medial knee joint region using ultrasound imaging in combination with electric stimulation.

An 83-year-old man had received weekly hyaluronic acid injections into the right knee joint for approximately 3 months at the orthopedic clinic, with unsuccessful outcomes. The patient had been consulting the Pain Management Clinic Department of our institute for approximately 12 years for postherpetic neuralgia in the left fifth and sixth thoracic vertebral regions and requested treatment for right knee pain. The patient had been prescribed 20 mg of duloxetine hydrochloride, 10 mg of myrogabalin besilate, and 1 mg of fentanyl citrate patch for postherpetic neuralgia. He complained of burning pain in the superior medial knee joint region, which exhibited mild edema, with a numeric rating scale of 7–8/10. A bilateral knee radiograph indicated mild osteoarthritis with Kellgren and Lawerence grade 1. We speculated the involvement of neuropathic pain and decided to perform PRF. Ultrasound scanning of an especially painful point revealed a cord-like structure between the vastus medialis and sartorius muscle (Fig. 1). After subcutaneous anesthesia, a guiding needle was inserted near the structure under ultrasound guidance and successfully obtained reproducible pain with less than 0.5 V of electric stimulation. The reproducible pain was obtained only when the needle tip was within a few millimeters of the cord-like structure, indicating that the structure was the peripheral branch of a nerve. PRF was performed below 42 °C for 180 s, followed by the administration of 0.45 mg of 0.15% ropivacaine and 4 mg of betamethasone. Thirty minutes after the procedure, the pain in the medial part of the right knee joint disappeared. After 1 week, he presented mild pain with a numeric rating scale of 2–3/10 at the medial knee joint region, and the edema had resolved. Three sessions of PRF successfully palliated the knee pain.

Fig. 1
figure 1

Ultrasound imaging at an especially painful point. A Ultrasound pre-scanning of an especially painful point in the superior medial knee joint region. B Ultrasound scanning reveals a cord-like structure (arrow heads) anterior to the sartorius muscle (surrounded by the white dashed line)

Several reports have described successful pain management of chronic neuropathic knee pain with PRF. These reports proposed several landmarks to identify the peripheral nerve branches [1, 2]; however, due to individual anatomical variations in innervation, the responsible nerve cannot be easily identified based only on physical findings [5]. Ultrasound imaging combined with an electrical stimulation to confirm reproducible pain could be a potential method for precisely identifying the responsive branch [6]. Such a careful diagnosis may help demonstrate the effectiveness of PRF targeting of peripheral nerves.

Availability of data and materials

Not applicable.



Pulsed radiofrequency


  1. Tan YL, Neo EJR, Wee TC. Ultrasound-guided genicular nerve blockade with pharmacological agents for chronic knee osteoarthritis: a systematic review. Pain Phys. 2022;25:E489-502.

    Google Scholar 

  2. Uematsu H, Osako S, Hakata S, Kabata D, Shintani A, Kawazoe D, et al. A double-blind, placebo-controlled study of ultrasound-guided pulsed radiofrequency treatment of the saphenous nerve for refractory osteoarthritis-associated knee pain. Pain Phys. 2021;24:E761–9.

    Article  Google Scholar 

  3. Yasar E, Kesikburun S, Kılıç C, Güzelküçük Ü, Yazar F, Tan AK. Accuracy of ultrasound-guided genicular nerve block: a cadaveric study. Pain Phys. 2015;18:E899-904.

    Google Scholar 

  4. Manickam B, Perlas A, Duggan E, Brull R, Chan VW, Ramlogan R. Feasibility and efficacy of ultrasound-guided block of the saphenous nerve in the adductor canal. Reg Anesth Pain Med. 2009;34:578–80.

    Article  PubMed  Google Scholar 

  5. Tran J, Peng PWH, Lam K, Baig E, Agur AMR, Gofeld M. Anatomical study of the innervation of anterior knee joint capsule: implication for image-guided intervention. Reg Anesth Pain Med. 2018;43:407–14.

    Article  PubMed  Google Scholar 

  6. Ferreira-Dos-Santos G, Hurdle MB, Gupta S, Tran J, Agur AMR, Clendenen SR. Revisiting the genicular nerve block: an up-to-date guide utilizing ultrasound guidance and peripheral nerve stimulation - anatomy description and technique standardization. Pain Phys. 2021;24:E177–83.

    Google Scholar 

Download references


Not applicable


No funding source for this letter to the editor.

Author information

Authors and Affiliations



SS, NI, and SF were responsible for the management of this case. SS wrote the manuscript and NI, SF, and HK supervised the manuscript. The authors read and approved the final manuscript.

Corresponding author

Correspondence to Satoshi Shimizu.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Written consent to report this case including an individual image was obtained from the patient.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shimizu, S., Iwashita, N., Fukui, S. et al. Ultrasound imaging with an electric stimulant was useful in pulsed radiofrequency for chronic knee pain in the medial region. JA Clin Rep 8, 92 (2022).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: