Drastic improvement of cardiac function after living-donor renal transplantation in a long-term hemodialysis patient with severe mitral regurgitation
JA Clinical Reports volume 8, Article number: 95 (2022)
Although there are reports of recovery of cardiac function after renal transplantation, the feasibility of renal transplantation in patients with low cardiac function remains controversial.
A 59-year-old Japanese male was scheduled to undergo living-donor renal transplantation (LDRT) under general anesthesia. Preoperative transthoracic echocardiography revealed severe mitral regurgitation (MR) and a left ventricular ejection fraction (LVEF) at 30%. LDRT was conducted prior to cardiac surgery with restrictive fluid management and close monitoring of cardiac function. The patient’s renal function improved promptly after the LDRT, and his hemodynamics were stable throughout the perioperative period. Along with improvements in the patient’s renal function and anemia, the patient’s cardiac function improved to LVEF 50% and achieved drastically improved MR as well as cardiac function, without intervention.
This case indicates that LDRT has the potential to improve cardiac function in patients who have been on hemodialysis for more than 20 years.
Renal transplantation for patients with end-stage renal disease (ESRD) has a high cardiovascular risk during the perioperative period. Avoiding renal transplantation has been the standard strategy for the proper use of grafts, especially for patients with severely impaired cardiac function . However, evidence that renal transplantation can improve these patients’ cardiac function has been accumulating . The indications for living-donor renal transplantation (LDRT) for patients with cardiac impairment remain controversial. In particular, it is unclear whether LDRT can improve low cardiac function status in patients on long-term dialysis. We report the case details of a long-term dialysis patient with severe mitral regurgitation (MR) and a low left ventricular ejection fraction (LVEF) whose cardiac function improved after he underwent LDRT.
The patient’s written consent to publish this case report was obtained.
A 59-year-old Japanese male (height 171 cm, weight 69.2 kg) was scheduled to undergo LDRT from his brother under general anesthesia. He had been treated for chronic kidney disease due to polycystic kidney disease, and he had begun hemodialysis 21 years ago. He had also been taking medications for atrial fibrillation (Af) and MR for 9 years, and he underwent a percutaneous coronary intervention to the left anterior descending artery for angina pectoris 5 years ago. There had been no history of heart failure symptoms or associated hospitalization since then.
The blood test revealed decreased kidney function with a serum creatinine of 10.49 mg/dL and blood urea nitrogen of 51 mg/dL, and mild anemia with hemoglobin of 10.0 g/dL. The patient’s brain natriuretic peptide value was 971 pg/mL. Transthoracic echocardiography before the LDRT showed severe MR and a left ventricular ejection fraction (LVEF) at 30%, with low cardiac output. Coronary computed-tomography angiography showed no stent stenosis but three-vessel disease was suspected, which led to the conclusion that cardiac dysfunction was due to ischemic cardiomyopathy. Restrictive pulmonary dysfunction with vital capacity of 2.7 L (65% of predictive value) was also observed. The priority of surgery for the patient’s severe MR or for his ESRD was discussed, and it was concluded that further preoperative assessment was required to determine the indications for surgery.
Transthoracic echocardiography and right heart catheterization were then conducted to evaluate the impacts of a preload reduction induced by arteriovenous shunt obstruction and of a dobutamine infusion on the patient’s cardiac output (CO) and pulmonary artery pressure. The preload reduction resulted in no changes in pulmonary hypertension or the severity of the patient’s MR, and a continuous intravenous dobutamine infusion increased his CO and pulmonary artery pressure (Table 1). The patient’s mitral valve had no mechanical abnormality, and the MR was secondary due to cardiac ischemia. Based on these findings, we decided to perform LDRT before cardiac surgery with restrictive fluid management and a close monitoring of the patient’s cardiac function.
Oral midazolam 10 mg and roxatidine acetate 75 mg were administered as an anesthetic premedication 1 h before the LDRT surgery. In addition to the standard ASA monitoring, the patient’s invasive artery pressure, pulmonary artery pressure, and CO were measured. Anesthesia was induced and maintained with propofol, ketamine, and fentanyl. After an administration of rocuronium 50 mg, the trachea was intubated without any complications. The end-tidal carbon dioxide was maintained at 35–40 mmHg. A continuous infusion of dobutamine 1 μg/kg/min effectively increased cardiac index from 2.6 to 3.4 L/min/m2 and maintained the urine outflow after graft anastomosis. The intraoperative data were as follows: 1570 mL crystalloid fluid administration, 450 mL colloid fluid administration, 327 g estimated blood loss, and 810 mL urine output; duration of surgery, 225 min; duration of anesthesia, 304 min. After the patient’s tracheal tube was displaced in the operating room, he was transferred to the intensive care unit (ICU) for the observation of cardiac and renal function. At 3 days post-LDRT, the serum creatinine level had decreased to 1.27 mg/dL, and although the patient gained 2 kg, his hemodynamics were stable without complaints.
During the postoperative course, the patient’s cardiac and renal function and anemia were dramatically improved (Fig. 1). As his cardiac function remained stable after the LDRT, cardiac surgery for his MR has been unnecessary (Fig. 2).
The priority of valvular surgery to non-cardiac surgery has been indicated by several guidelines; however, the influence of end stage renal disease on it has not been considered in those guidelines, and priority of valve surgery to renal transplantation is not known . Normal structure of the mitral valve leaflets is often maintained in patients with functional MR secondary to decreased left ventricular function as observed in our case . Renal transplantation may thus precede cardiac surgery in patients in whom improvement in cardiac function is expected after renal transplantation. However, the perioperative outcome data are not yet sufficient to justify a prior renal transplantation in patients with asymptomatic severe valvular lesions, and further studies are needed to accumulate such data.
The key finding in the present case is that even in a patient who had been on dialysis for > 20 years, improved renal function after an LDRT was accompanied by improved cardiac function, and unnecessary intervention to the heart was avoided. Several reports have indicated that renal transplantation recovered cardiac function in patients who were younger with shorter duration of dialysis than the present case [5, 6]. Renal transplantation also improved cardiac function due to severe MR in a patient with diabetic nephropathy before introducing hemodialysis . According to Wali et al., approx. 70% of renal transplant recipients with an LVEF ≤ 40% showed an improvement of their LVEF to ≥ 50% at 2 months after renal transplantation . They also revealed that long-term dialysis was a factor preventing normalization of the LVEF. Based on our experience with the present patient, we speculate that long-term hemodialysis does not prohibit an improvement in cardiac function after renal transplantation.
Renal failure and cardiac disease are closely related . Mild anemia, probably due to renal failure existed before surgery. Because anemia itself increases the ischemia, oxidative stress, and inflammation , it may have worsened the cardiac function of this patient. Cardiac function was improved after renal transplantation as shown by the decrease of BNP. Recovery of renal function improved anemia through an increase of erythropoietin secretion, which may have contributed to the improvement in the cardiac function.
Perioperative management after renal transplantation often involves aggressive fluid loading to promote diuresis in order to avoid intravascular dehydration. However, in our patient’s case, fluid loading and dilution caused anemia and excessive preload, which are likely to easily cause heart failure due to severe MR. A pulmonary artery catheter was therefore inserted in order to monitor changes in the patient’s CO, while minimal IV fluids and catecholamines were administered.
This case report demonstrates that even in a patient who has been on dialysis for more than 20 years, the improved renal function after LDRT can improve the patient’s cardiac function and avoid unnecessary intervention to the heart. The present patient with severe MR and impaired cardiac function was able to undergo surgery and obtained significant benefit after LDRT. Renal transplantation should thus be considered as a treatment for ESRD patients with decreased cardiac function.
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End-stage renal disease
Intensive care unit
Living-donor renal transplantation
Left ventricular ejection fraction
Siedlecki A, Foushee M, Curtis JJ, Gaston RS, Perry G, Iskandrian AE, et al. The impact of left ventricular systolic dysfunction on survival after renal transplantation. Transplantation. 2007;84:1610–7.
Melchor JL, Gracida C, Orihuela O. Improvement of mitral dysfunction after kidney transplantation. Transplant Proc. 2002;34:396–7.
Jha AK, Lata S. Kidney transplantation in valvular heart disease and pulmonary hypertension: consensus in waiting. Clin Transplant. 2021;35:e14116.
Naser N, Dzubur A, Kusljugic Z, Kovacevic K, Kulic M, Sokolovic S, et al. Echocardiographic assessment of ischaemic mitral regurgitation, mechanism, severity, impact on treatment strategy and long term outcome. Acta Inform Med. 2016;24:172–7.
Matsumoto S, Kimura S, Muto N, Yamanoi T, Higashi T, Nakamura K, et al. A case of end-stage renal disease with significant cardiac function improvement following living donor renal transplantation. J Jpn Soc Intensive Care Med. 2013;20:93–4.
Kobori G, Moroi S, Yoshida H, Yamamoto S, Kamono T, Okuno H, et al. [Marked improvement of cardiac function following renal transplantation: a case report] Hinyokika kiyo. Acta urologica Japonica. 2003;49:17-9. Japanese.
Oki R, Hidaka S, Moriya H, Miyake K, Oda Y, Matsui K, et al. Remarkable improvement of cardiac function after pre-emptive kidney transplant in a patient with severe mitral regurgitation accompanied by low cardiac function: a case report. Transplant Proc. 2019;51:548–50.
Wali RK, Wang GS, Gottlieb SS, Bellumkonda L, Hansalia R, Ramos E, et al. Effect of kidney transplantation on left ventricular systolic dysfunction and congestive heart failure in patients with end-stage renal disease. J Am Coll Cardiol. 2005;45:1051–60.
Ronco C, Haapio M, House AA, Anavekar N, Bellomo R. Cardiorenal syndrome. J Am Coll Cardiol. 2008;52:1527–39.
Silverberg DS, Wexler D, Iaina A, Steinbruch S, Wollman Y, Schwartz D. Anemia, chronic renal disease and congestive heart failure--the cardio renal anemia syndrome: the need for cooperation between cardiologists and nephrologists. Int Urol Nephrol. 2006;38:295–310.
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Noguchi, S., Saito, J., Hashiba, E. et al. Drastic improvement of cardiac function after living-donor renal transplantation in a long-term hemodialysis patient with severe mitral regurgitation. JA Clin Rep 8, 95 (2022). https://doi.org/10.1186/s40981-022-00583-8