A 62-year-old man was admitted to our hospital for the removal of a suspected metastatic brain tumor. He had suffered from gait disturbance and visual field defects for 3 months. He has recently developed left hemiplegia due to multiple brain lesions. He had no specific past history aside from being a heavy smoker. The main brain tumor was located in the right occipital lobe, and the imaging study suggested that it was a metastatic tumor from lung cancer. A subsequent chest CT revealed a large solid tumor (maximum diameter, 72.25 mm) in the mediastinum (Fig. 1a). As for the main bronchus, the maximum reduction in the cross-sectional area was estimated to be 50 % in the side just rostral to the bifurcation (Fig. 1b), and the length of the stenosis was approximately 35 mm. In addition, the bilateral innominate veins were completely obstructed before merging into SVC, and SVC was involved in the mass and was completely compressed. Despite the imaging findings, he did not show any cardiopulmonary symptoms or upper body edema. Initially, we intended to consult a pulmonologist for further examination before craniotomy; however, the removal of the tumor was prioritized because of progressive neurological symptoms.
Peripheral 20-G and 22-G intravenous lines were secured at the right forearm and the right back of the hand. General anesthesia was induced with 100 mg of propofol plus 100 μg of fentanyl, and neuromuscular blockade was achieved with 50 mg of rocuronium. Manual ventilation with a mask was easily performed. Tracheal intubation with a 7.5 mm silicone reinforced tracheal tube was performed uneventfully. Before tube fixation, we confirmed that the distal tube end was positioned to avoid injury to the stenotic part of the trachea using a fiberoptic bronchoscope. General anesthesia was maintained with 1–1.5 % of sevoflurane, 0.05–0.1 μg/kg/min of remifentanil, and 10–15 mg/h of rocuronium. Transient hypotension was observed during induction of the anesthesia; however, it was treated using 8 mg of ephedrine. Craniotomy and removal of the brain tumor was performed in the left park-bench position. During the surgery, hemodynamic status fluctuated and was unstable, which became particularly apparent after an increase in urine output by mannitol administration. To maintain systolic blood pressure at 80–90 mmHg through the procedures, continuous, massive infusion of noradrenaline (0.05–0.07 μg/kg/min) was required. The operation time for the procedures was prolonged to 4 h and 25 min probably because of poor brain relaxation. Fluid balance including crystalloids and colloids infusion (5600 ml), blood products transfusion (560 ml), urine output (2650 ml), and blood loss (625 ml) was 2885 ml.
After the surgery, the patient was turned to the supine position. Massive facial edema was apparent, and the bilateral upper extremities were significantly swollen. Immediately, a bronchoscopic examination was performed to evaluate the patency of the trachea, which revealed a worsened stenotic lesion. Contrary to our expectation, the respiratory condition of the patient was not impaired. Although tracheal stenting may have been a therapeutic option for this condition, we hesitated to select this option because of lack of detailed information regarding the mediastinal tumor. After the administration of 200 mg of sugamadex, the patient’s spontaneous breathing was sufficient; however, he did not regain consciousness. The tracheal tube was then removed. Critical strider accompanied with tachycardia and hypertension was observed. It did not seem likely that the patient’s respiratory condition would rapidly improve. Consequently, reintubation was performed to maintain patency of the trachea, which was confirmed by a subsequent bronchoscopic examination. The tracheal wall was supported by the tracheal tube although the tracheal tube did not pass the stenotic lesion. A head and chest CT was performed before the patient was transferred to the intensive care unit (ICU). Head CT revealed remaining brain edema with mild midline shift despite removal of the main lesion (Fig. 2). Chest CT showed that the maximum reduction in the cross-sectional area of the trachea was estimated to be >90 % (Fig. 3). Compared with the size of the tumor before the surgery, the tumor at the almost same CT slice level appeared to increase in size (Fig. 1-b and Fig. 3).
After admission to ICU, the patient remained sedated under mechanical ventilation. He was placed in the Fowler’s position to facilitate blood flow from the upper body. Simultaneously, diuretics (mannitol and furosemide) were used for edema treatment. Owing to the intensive care, the stenotic lesion improved dramatically. On the day following craniotomy, considering the progressive nature of the mediastinal tumor, tracheal stenting using a covered metal stent 60 mm long (Ultraflex™, Boston Scientific Japan, Tokyo) was performed (Fig. 4). Following the successful tracheal stenting, the patient regained consciousness immediately after cessation of sedatives. His trachea was extubated, and his respiratory condition did not deteriorate. Finally, he was discharged from ICU and underwent chemotherapy and radiotherapy. He was discharged from the hospital 3 months after the surgery. Although the patient did not develop SVC syndrome, he died from asphyxiation after coughing up blood at home 2 months after being discharged.
