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Table 1 Results of skin tests

From: Intraoperative anaphylaxis due to aprotinin after local application of fibrin sealant diagnosed by skin tests and basophil activation tests: a case report

Skin prick test

Intradermal test

Drug

Concentration of the stock solution (mg/mL)

Judgment

Wheal (mm)

Flare (mm)

Concentration of the stock solution (mg/mL)

Judgment

Wheal (mm)

Flare (mm)

Saline

9

  

9

  

Histamine

10

+

5

10

0.01

+

9

20

Propofol

10

  

1

  

Rocuronium

10

  

0.1

  

Remifentanil

0.05

  

0.005

  

Fentanyl

0.05

  

0.005

  

Cefazolin

20

  

2

  

Flurbiprofen

10

  

1

  

Lidocaine

10

  

1

  

Ropivacaine

2

  

0.2

  

Felt

NA

  

NA

ND

  

Vial no. 1

80

  

8

  

Vial no. 2

0.17

+

5

6

0.017

+

7

12

Vial no. 3

250a

  

25a

  
  1. aUnits/mL
  2. SPT skin prick test, IDT intradermal test, NA not applicable, ND no data
  3. Saline and histamine were used as negative and positive controls, respectively. SPT was started with a 100-fold dilution of stock solution, and a tenfold dilution and stock solution were inspected. The SPTs for the felt were performed by puncturing a bifurcated needle from above the felt. Histamine and vial no. 2 showed a positive result at the stock solution. Subsequently, IDTs were performed. After confirming a negative reaction for saline and a positive reaction for histamine, vial no. 2 showed a positive reaction at a 100-fold dilution of the stock solution, that is, 0.00017 mg/ml. Other tested agents did not result in a positive reaction with a 100-fold dilution of the stock solution. SPT reactions were deemed positive when the diameter of the wheal was equal to or 3 mm larger than in the negative control, or equal to at least half that in the positive control after 20 min. IDT reactions were deemed positive when the diameter of the wheal was equal to at least twice that of the post-injection wheal after 20 min [6]