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Table 1 The patients’ preoperative characteristics, anesthesia profiles and the drugs administered during anesthesia

From: Hypotension caused by oral administration of 5-aminolevulinic acid persists after surgery in patients undergoing transurethral resection of bladder tumor under spinal anesthesia

 

Control group (n = 63)

ALA group (n = 66)

P value

Age (years)

71 ± 11

74 ± 10

0.27

Height (cm)

162 ± 15

161 ± 14

0.58

Weight (kg)

65 ± 17

65 ± 18

0.97

Sex (male/female)

59 (94%)/4 (6%)

55 (83%)/11 (17%)

0.07

Regular use of antihypertensive drug

24 (38%)

23 (35%)

0.70

Regular use of renin-angiotensin system inhibitor

14 (22%)

11 (17%)

0.42

Duration of surgery (minutes)

43 ± 25

44 ± 20

0.84

Duration of anesthesia (minutes)

75 ± 28

80 ± 22

0.25

Dose of 0.5% hyperbaric bupivacaine of spinal anesthesia (mL)

3.1 ± 0.3

3.0 ± 0.3

0.20

Sensory block level just before surgerya

T8 (T2–T11)

T6 (T2–L1)

0.26

Sensory block level at the end of surgerya

T6 (T2–T12)

T5 (T2–T12)

0.49

Intravenous fluid volume during anesthesia (mL)

570 ± 191

758 ± 284

< 0.001

Use of vasopressorsb

10 (16%)

47 (71%)

< 0.001

Use of ephedrine

8 (13%)

37 (56%)

< 0.001

Total dose of ephedrine (mg)

1.0 ± 3.0

6.9 ± 9.0

< 0.001

Use of phenylephrine

6 (10%)

30 (45%)

< 0.001

Total dose of phenylephrine (mg)

0.013 ± 0.042

0.21 ± 0.34

< 0.001

  1. Values are presented as mean ± standard deviation or number (%)
  2. aMedian (maximum-minimum)
  3. bEphedrine or phenylephrine or both were used
  4. ALA aminolevulinic acid