Opposite changes in blood pressure and pulse rate in two patients with distigmine and rivastigmine intoxication

JA Clinical Reports

Table 2 Previous reports showing distigmine and rivastigmine intoxication

	BP, mmHg	PR, bpm	Age, years	Sex	Serum ChE, IU/L	Ref
(A) Distigmine	69/40	60	77	F	8	case #1
	Shock		62	M	7	[4]
	Shock		72	F	11	[5]
	Shock		76	F	11	[6]
	ND	30	77	M	ND	[7]
	50 (palpation)	40	78	M	13	[8]
	60/34	56	75	M	4	[9]
	88/50	48	70s	M	6	[10]
	93/52	32	71	M	41	[11]
	97/46	55	54	F	3	[12]
	97/64	50	40s	F	17	[13]
	100 (palpation)	56	72	M	1	[14]
	100/60	102	73	F	76	[15]
	104/60	56	73	M	16	[16]
	104/66	94	63	M	0.06ΔpH*	[17]
	119/37	39	67	F	26	[18]
	120/68	88	65	M	564 (range, 3000-6500)	[19]
	120/76	118	56	M	73	[20]
(B) Rivastigmine	202/86	83	91	F	22	case #2
	120/80	89	70	F	ND	[3]
	150/80	106	87	M	ND	[21]
	169/119	88	38	M	947 U/g hemoglobin (range, 2710-11510 U/g)	[22]
	180/90	79	59	M	6.0 μkat/L (range, 60–190 μkat/L)	[23]
	186/61	83	91	F	35	[24]
	207/85	101	80	F	ND	[25]

Vital signs and serum cholinesterase (ChE) upon initial presentation are summarized for patients A (distigmine) and B (rivastigmine)
BP blood pressure, PR pulse rate, ND not determined
*Reference article did not include the reference range