Skip to main content

Table 2 Confidence assessment in the risk ratio of each comparison and outcome

From: Respiratory support strategy in adults with acute hypoxemic respiratory failure: a systematic review and network meta-analysis

  Risk of bias across studies Imprecision Heterogeneity Indirectness Publication bias Incoherence Confidence in relative risk of the event
Short-term mortality
  HFNO vs SOT Undetected Major concerns (a)
95% CI (0.66–1.20)
No concerns
95% PI (0.47–1.70)
Low Not suggested Some concerns
P=0.07*
Low
  NIV vs SOT Undetected No concern
95% CI (0.61–0.95)
Major concerns (b)
95% PI (0.42–1.39)
Low Not suggested No concerns
P=0.05*
Low
  IMV vs SOT Undetected Major concerns (a)
95% CI (0.57–1.78)
No concerns
95% PI (0.45–2.29)
Low Not suggested Major concerns(c)
P= 0.01**
Very low
  HFNO vs IMV Undetected Major concerns (a)
95% CI (0.47–1.65)
No concerns
95% PI (0.37–2.10)
Low Not suggested Major concerns(c)
P=0.01**
Very low
  NIV vs IMV Undetected Major concerns (a)
95% CI (0.45–1.27)
No concerns
95% PI (0.34–1.65)
Low Not suggested Major concern(c)
P= 0.01**
Very low
  NIV vs HFNO Undetected Major concerns (a)
95% CI (0.61–1.20)
No concern
95% PI (0.44–1.67)
Low Not suggested Major concern(c)
P=0.01*
Very low
Endotracheal intubation
  HFNO vs SOT Undetected Some concerns
95% CI (0.61–1.11)
Some concerns
95% PI (0.41–1.64)
Low Not suggested No concern
P= 0.50*
Moderate
  NIV vs SOT Undetected No concern
95% CI (0.51–0.79)
Major concerns (b)
95% PI (0.33–1.22)
Low Not suggested No concern
P= 0.85*
Low
  NIV vs HFNO Undetected Some concerns
95% CI (0.56–1.06)
Some concerns
95% PI (0.38–1.56)
Low Not suggested No concern
P=0.24*
Moderate
  1. CI confidence interval, SOT standard oxygenation therapy, HFNO high-flow nasal oxygen, IMV invasive mechanical ventilation, NIV noninvasive ventilation, PI prediction interval
  2. *We used a side-splitting approach as a local method
  3. **We used the design-by-treatment model as a global method
  4. aConfidence interval extends into clinically important effects in both directions
  5. bPrediction interval extends into clinically important effects in bothdirections
  6. cP value of inconsistency was <0.05