Evaluation of the effect of apixaban using a viscoelastic coagulation assay with Russell’s viper venom reagent

JA Clinical Reports

Table 1 Perioperative coagulation tests

Coagulation test	Normal range	After anesthesia induction	At end of surgery	POD 1	POD 6
Fibrinogen (mg/dL)	150–400^a	219	220	249	399
APTT (s)	24–36^a	40.3	38.0	38.5	34.7
PT (%)	70–110^a	42	49	59	69
PT-INR	0.9–1.1^a	1.7	1.5	1.3	1.2
CT in RVV test (s)	48–77^b	167	126	73	93
CT in ECA test (s)	68–100^b	76	77	73	71
Anti-Xa activity (IU/mL)	< 0.1^b	1.69	1.12	0.06	0.78

APTT Activated partial thromboplastin time, CT Clotting time, ECA Ecarin, INR International normalized ratio, POD Postoperative day, PT Prothrombin time, RVV Russell viper venom, Xa Activated factor X
^aBased on the institutional reference values
^bBased on the manufacturer’s reference values