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Table 2 Univariable and multivariable associations between absolute or relative thresholds and acute kidney injury (N=6296)

From: Analysis of intraoperative modifiable factors to prevent acute kidney injury after elective noncardiac surgery: intraoperative hypotension and crystalloid administration related to acute kidney injury

 

Duration

Total (n=6296)

AKI (n=431)

Unadjusted OR (95% CI)

Adjusted ORa (95% CI)

Absolute thresholds

 <90 mmHg

0 min

222

14 (6.03%)

Ref.

Ref.

1≤ <5 min

274

16 (5.84%)

0.92 (0.43 to 1.95)

0.78 (0.34 to 1.77)

5≤ <20 min

997

55 (5.52%)

0.86 (0.48 to 1.63)

0.80 (0.42 to 1.63)

20≤

4803

346 (7.21%)

1.14 (0.68 to 2.07)

0.80 (0.44 to 1.57)

Trend

  

1.11 (0.97 to 1.30)

0.96 (0.82 to 1.14)

 <85 mmHg

0 min

387

26 (6.72%)

Ref.

Ref.

1≤ <5min

489

27 (5.52%)

0.81 (0.46 to 1.41)

0.69 (0.37 to 1.28)

5≤ <20min

1593

72 (4.52%)

0.65 (0.41 to 1.05)

0.60 (0.37 to 1.03)

20≤

3825

306 (8.00%)

1.20 (0.80 to 1.86)

0.86 (0.54 to 1.41)

Trend

  

1.20 (1.06 to 1.36)

1.05 (0.92 to 1.21)

 < 80 mmHg

0 min

668

39 (5.84%)

Ref.

Ref.

1≤ <5 min

908

46 (5.07%)

0.86 (0.55 to 1.33)

0.79 (0.49 to 1.27)

5≤ <20 min

2169

121 (5.58%)

0.95 (0.65 to 1.37)

0.87 (0.58 to 1.33)

20≤

2551

225 (8.82%)

1.55 (1.09 to 2.21)

1.08 (0.74 to 1.63)

Trend

  

1.24 (1.12 to 1.39)

1.08 (1.03 to 1.22)

 <75 mmHg

0 min

1199

69 (5.75%)

Ref.

Ref.

1≤ <5 min

1415

67 (4.73%)

0.81 (0.57 to 1.15)

0.79 (0.54 to 1.15)

5≤ <20 min

2480

160 (6.45%)

1.12 (0.84 to 1.51)

1.04 (0.76 to 1.45)

20≤

1202

135 (11.23%)

2.07 (1.54 to 2.82)

1.41 (1.00 to 2.00)

Trend

  

1.32 (1.19 to 1.46)

1.16 (1.04 to 1.30)

 < 70 mmHg

0 min

1980

114 (5.76%)

Ref.

Ref.

1≤ <5 min

2071

118 (5.70%)

0.98 (0.75 to 1.28)

0.90 (0.68 to 1.20)

5≤ <2 0min

1881

152 (8.08%)

1.43 (1.11 to 1.85)

1.09 (0.82 to 1.44)

20≤

360

47 (12.91%)

2.45 (1.71 to 3.52)

1.60 (1.06 to 2.38)

Trend

  

1.30 (1.17 to 1.44)

1.12 (1.00 to 1.26)

Relative thresholds

 < 85%

0 min

58

3 (4.92%)

Ref.

Ref.

1≤ <5 min

113

7 (5.83%)

1.19 (0.32 to 5.71)

1.30 (0.27 to 9.55)

5≤ <20 min

410

17 (3.98%)

0.80 (0.25 to 3.50)

0.98 (0.24 to 6.70)

20≤

5284

404 (7.10%)

1.47 (0.54 to 6.07)

1.72 (0.48 to 11.14)

Trend

  

1.36 (1.06 to 1.83)

1.32 (0.98 to 1.81)

 <80%

0 min

133

7 (5.26%)

Ref.

Ref.

1≤ <5 min

247

9 (3.64%)

0.68 (0.24 to 1.94)

0.68 (0.26 to 2.21)

5≤ <20 min

664

38 (5.72%)

1.09 (0.50 to 2.72)

1.32 (0.54 to 3.74)

20≤

5252

377 (7.18%)

1.39 (0.69 to 3.30)

1.58 (0.70 to 4.31)

Trend

  

1.28 (1.06 to 1.56)

1.29 (1.05 to 1.59)

 < 75%

0 min

278

13 (4.68%)

Ref.

Ref.

1≤ <5 min

446

20 (4.48%)

0.95 (0.47 to 2.00)

0.94 (0.44 to 2.11)

5≤ <20 min

1025

63 (6.15%)

1.33 (0.74 to 2.56)

1.44 (0.75 to 2.95)

20≤

4547

335 (7.37%)

1.62 (0.95 to 3.00)

1.74 (0.96 to 3.45)

Trend

  

1.24 (1.08 to 1.43)

1.25 (1.08 to 1.47)

 <70%

0 min

532

27 (5.08%)

Ref.

Ref.

1≤ <5 min

713

44 (6.17%)

1.23 (0.75 to 2.03)

1.14 (0.68 to 1.97)

5≤ <20 min

1448

78 (5.39%)

1.06 (0.68 to 1.69)

1.09 (0.68 to 1.81)

20≤

3603

282 (7.83)

1.58 (1.07 to 2.43)

1.58 (1.03 to 2.52)

Trend

  

1.61 (0.73 to 3.21)

1.19 (1.06 to 1.35)

 <65%

0 min

988

57 (5.77%)

Ref.

Ref.

1≤ <5 min

1091

63 (5.77%)

1.00 (0.69 to 1.45)

0.99 (0.66 to 1.47)

5≤ <20 min

1684

101 (6.00%)

1.04 (0.74 to 1.46)

1.08 (0.76 to 1.56)

20≤

2533

210 (8.29%)

1.47 (1.09 to 2.01)

1.49 (1.07 to 2.09)

Trend

  

1.16 (1.06 to 1.28)

1.16 (1.05 to 1.29)

  1. aAdjusted for sex, age, ASAPS, beta blockers, CCBs, diuretics, baseline eGFR, hypertension, coronary artery disease, diabetes mellitus, cerebrovascular disease, mixed obstructive and restrictive disease, respiratory failure, hyperthyroidism, depression, ileus, anesthesia time, hemorrhage, crystalloid administration, RBC transfusion, urine as a categorical variable and surgical procedure type
  2. AKI acute kidney injury, OR odds ratio, ASAPS American Society of Anesthesiologists Physical Status, CCB calcium channel blocker, eGFR estimated glomerular filtration rate, RBC red blood cells