Identification of risk factors for post-induction hypotension in patients receiving 5-aminolevulinic acid: a single-center retrospective study

JA Clinical Reports

Table 1 Patient background and pre-anesthesia data

		Group N (N = 51)	Group L (N = 121)	P value
Age	years	71 [64, 81]	74 [66, 81]	0.71
Female	N (%)	7 (14)	38 (31)	0.02*
Height	cm	162 [158, 168]	161 [155, 168]	0.20
Weight	kg	60 [52, 69]	59 [52, 69]	0.85
Body mass index	kg/m²	22.5 [20.2, 24.8]	22.8 [20.8, 25.1]	0.40
ASA-PS (1/2/3)	N	6/44/1	8/96/17
ASA-PS = 3	N (%)	1(2)	17 (14)	0.01*
TUR-Bt	N (%)	42 (82)	64 (53)	< 0.001*
Preoperative condition
Heart disease	N (%)	1 (2)	20 (17)	0.009*
Atrial fibrillation or PAf	N (%)	1 (2)	13 (11)	0.07
Other disease	N (%)	0 (0)	12 (10)	0.02*
Diabetes mellitus	N (%)	7 (14)	19 (16)	0.82
Liver dysfunction	N (%)	3 (6)	7 (6)	1.00
eGFR	ml/m²	73 [57, 84]	69 [57, 82]	0.64
Hypertension	N (%)	26 (51)	66 (55)	0.74
Use of calcium blocker	N (%)	21 (41)	52 (43)	0.87
Use of RAS inhibitor	N (%)	15 (29)	38 (31)	0.86
Use of psychiatric drugs	N (%)	1 (2)	5 (4)	0.67
Preoperative hematocrit	%	39.6 [37.7, 42.8]	38.5 [35.9, 42.0]	0.06
Pre ALA systolic BP	mmHg	128 [117, 143]	124 [114, 138]	0.17
Pre ALA mean BP	mmHg	92 [84, 101]	91 [84, 97]	0.41
Pre ALA heart rate	beats/min	65 [60, 74]	66 [60, 72]	0.98
ALA to anesthesia induction	min	167 [140, 202]	158 [142, 187]	0.51
Systolic BP before induction	mmHg	130 [117, 150]	122 [109, 136]	0.01*
Mean BP before induction	mmHg	92 [84, 102]	90 [84, 97]	0.41
Difference systolic BP	mmHg	4 [-7, 16]	-2 [-15, 11]	0.13
Difference mean BP	mmHg	2 [-4, 11]	-10 [-3, 7]	0.01*
Heart rate before induction	beats/min	65 [60, 74]	66 [60, 72]	0.98
General anesthesia	N (%)	13 (25)	107 (88)	<0.001*

N number, ASA-PS American Society of Anesthesiologists physical status classification, TUR-Bt transurethral resection of the bladder tumor, PAf paroxysmal Af, eGFR estimated glomerular filtration rate, RAS renin-angiotensin system, ALA 5-aminolevulinic acid, BP blood pressure, Pre ALA before 5-ALA intake, ALA to anesthesia induction time from 5-ALA intake to anesthesia induction, before induction before anesthesia induction, Difference difference in BP before 5-ALA intake and before anesthesia induction ([BP anesthesia induction]−[BP before5-ALA intake])
*p < 0.05