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Table 1 Characteristics of patients in the study cohort that were assessed using univariate and multivariate analysis as risk factors for the presence of residual blast cells in peripheral blood on day 8 following prednisone chemotherapy

From: Association between the choice of anesthesia method and reactivity to chemotherapy in children with acute lymphocytic leukemia: a preliminary retrospective cohort study

  Univariate analysis Multivariate analysis
  No blasts (n = 24) Residual blasts (n = 33) Crude OR (95% CI) P value Adjusted OR (95% CI) P value
Age (months) 53 (37–71) 74 (50–148) 1.01 (1.00–1.02) 0.074 1.008 (0.996–1.019) 0.18
Height (cm) 99.2 (91.2–110) 125 (103–149) 1.04 (1.01–1.07) 0.013   
Weight (kg) 16.3 (12.9–20.2) 19.8 (16–35) 1.05 (1.00–1.10) 0.053   
Gender (male) (%) 9 (37.5) 20 (60.6) 0.45 (0.15–1.33) 0.67   
ASA-PSIII (%) 2 (8.3) 2 (6.1) 0.66 (0.086–5.02) 0.53   
Operation time (min) 29 (23–47) 27 (22–30) 0.97 (0.93–1.01) 0.15   
Anesthesia time (min) 83 (73–92) 83 (74–92) 0.99 (0.97–1.01) 0.45   
Anesthesia method (sevoflurane) (%) 12 (50.0) 7 (21.2) 0.27 (0.085–0.86) 0.045 2.31 (0.70–7.65) 0.17
WBC > 50,000/μL at diagnosis (%) 2 (8.3) 8 (24.2) 3.23 (0.619–16.9) 0.18   
Central nervous invasion (%) 1 (4.2) 5 (15.2) 3.79 (0.413–34.8) 0.39   
Mediastinal invasion (%) 0 (0) 0 (0)     
Hypodiploid (%) 1 (4.2) 0 (0) 0.393 (0.284–0.554) 0.40   
Genetic risk (%) 1 (4.2) 6 (18.2) 4.714 (0.528–42.10) 0.22   
  1. Data are expressed as median (25th–75th percentile) or n (%). Residual blast cells: leukemic blast cell count in peripheral blood on day 8 following prednisone chemotherapy > 0/μL. Hypodiploid: fewer than 45 chromosomes. Genetic risk: Evidence of MLL-AF4, MLL reconstitution and/or E2A-HLF
  2. OR odds ratio, CI confidence interval, ASA-PS American Society of Anesthesiologists physical status, WBC white blood cell count