Effect of sex and polymorphisms of CYP2B6 and UGT1A9 on the difference between the target-controlled infusion predicted and measured plasma propofol concentration

Fujita, Ai; Hayamizu, Kengo; Yoshihara, Tatsuya; Zaitsu, Masayoshi; Shiraishi, Fumie; Arima, Hisatomi; Matsuo, Kazumasa; Shiokawa, Kanako; Setoguchi, Hidekazu; Sasaguri, Toshiyuki

doi:10.1186/s40981-018-0196-8

JA Clinical Reports

Table 3 Regression coefficients of sex and CYP2B6 516G > T polymorphisms for performance errors estimated with linear regression, adjusted for background characteristics and clinical factors

From: Effect of sex and polymorphisms of CYP2B6 and UGT1A9 on the difference between the target-controlled infusion predicted and measured plasma propofol concentration

Characteristics	Beta (95% confidence interval)
Characteristics	Model 1	p value	Model 2^a	p value	Model 3^b	p value
Sex (female)	− 9.13 (− 16.40 to − 1.85)	0.015	− 8.84 (− 16.26 to − 1.43)	0.020	− 5.43 (− 12.53 to 1.68)	0.132
Age (years)			− 0.20 (− 0.88 to 0.48)	0.566	0.13 (− 0.48 to 0.73)	0.679
BMI (kg/m²)			0.60 (− 2.07 to 3.27)	0.656	0.53 (− 1.74 to 2.81)	0.641
mBP (mmHg)					0.80 (0.07 to 1.54)	0.033
HR (bpm)					− 0.89 (− 1.43 to − 0.34)	0.002
Volume of intravenous fluid (ml/kg)					− 0.63 (− 1.17 to − 0.09)	0.024
Surgical site
Head and neck					Reference
Upper abdomen					1.08 (−11.61 to 13.77)	0.865
Lower abdomen					− 4.79 (−22.73 to 13.15)	0.595
Head down position					2.98 (− 11.07 to 17.04)	0.673
Pneumoperitoneum					− 7.68 (− 20.33 to 4.96)	0.229
R ²	0.09		0.10		0.45
CYP2B6 polymorphisms
516GG	Reference		Reference		Reference
516GT	− 16.93 (− 31.11 to − 2.74)	0.020	− 15.68 (− 30.55 to − 1.11)	0.036	− 8.72 (− 21.54 to 4.11)	0.179
516TT	17.65 (− 4.53 to 39.83)	0.112	15.68 (− 7.42 to 38.77)	0.180	12.12 (− 7.66 to 31.90)	0.225
Age (years)			− 0.05 (− 0.74 to 0.64)	0.884	0.20 (− 0.42 to 0.81)	0.529
BMI (kg/m²)			0.84 (− 1.89 to 3.57)	0.542	0.62 (− 1.70 to 2.94)	0.594
mBP (mmHg)					0.98 (0.26 to 1.71)	0.009
HR (bpm)					− 0.90 (− 1.45 to − 0.34)	0.002
Volume of intravenous fluid (ml/kg)					− 0.62 (− 1.17 to − 0.08)	0.027
Surgical site
Head and neck					Reference
Upper abdomen					0.56 (− 12.31 to 13.43)	0.931
Lower abdomen					− 0.67 (− 18.06 to 16.72)	0.939
Head down position					2.37 (− 11.85 to 16.58)	0.740
Pneumoperitoneum					− 9.12 (− 21.69 to 3.46)	0.152
R ²	0.09		0.09		0.44

^aAdjusted for age and BMI (model 2)
^bAdditional adjustment for mBP, HR, volume of intravenous infusion, surgical site, head down position, and pneumoperitoneum (Model 3)
BMI body mass index, mBP mean blood pressure, HR heart rate

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