Effect of sex and polymorphisms of CYP2B6 and UGT1A9 on the difference between the target-controlled infusion predicted and measured plasma propofol concentration

JA Clinical Reports

Table 1 Baseline characteristics and clinical factors of the study subjects stratified by sex

Characteristics	Male (n = 48) Mean ± SD or number (%)	Female (n = 21) Mean ± SD or number (%)	p value^a
Performance error (%)	28.7 ± 28.5	10.5 ± 26.2	0.015
Age (years)	66.0 ± 10.7	66.5 ± 11.1	0.872
BMI (kg/m²)	23.3 ± 2.9	22.5 ± 2.4	0.279
CYP2B6 516G > T
GG	35 (73)	13 (62)	0.198
GT	10 (21)	10 (38)
TT	31 (6)	0 (0)
Volume of intravenous fluid (mL/kg)	31.5 ± 11.9	32.4 ± 13.7	0.773
mBP (mmHg)	67.1 ± 8.9	63.8 ± 8.5	0.160
HR (bpm)	62.8 ± 11.2	67.8 ± 11.6	0.096
Surgical site (n)
Head and neck/upper abdomen/lower abdomen	25/ 9/ 15	16/ 5/ 0	0.015
Surgical position (n)
Flat position/head down position	37/ 11	21/ 0	0.017
Pneumoperitoneum (n)	3	2	0.629

^at test or chi-square test
Volume of intravenous fluid means the total infusion volume from commencement of propofol infusion to the time of blood sample collection. Blood pressure and heart rate were recorded at the time of blood sample collection. BMI body mass index, mBP mean blood pressure, HR heart rate