Table 1 Ventilator setting and clinical parameters during ECMO therapy
POD0 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
At the ED | Pre-ECMO | On ECMO | ICU admission | POD1 | POD2 | POD3 | POD4 | POD5 | POD6 (after weaning off ECMO) | ||
Mechanical ventilation | Mode | – | N/A | A/C (PC) | A/C (PC) | A/C (PC) | A/C (PC) | A/C (PC) | A/C (PC) | A/C (PC) | A/C (PC) |
FiO2 | – | 1 | 1 | 0.4 | 0.6 | 0.5 | 0.4 | 0.4 | 0.5 | 0.5 | |
PEEP (cmH2O) | – | N/A | 15 | 10 | 15 | 15 | 15 | 12 | 14 | 12 | |
Plateau pressure (cmH2O) | – | N/A | 30 | 20 | 23 | 23 | 20 | 25 | 26 | 22 | |
Frequency (/min) | – | N/A | 10 | 6 | 6 | 6 | 6 | 10 | 12 | 12 | |
Tidal volume (ml) | – | N/A | 100 | 140 | 120 | 150 | 150 | 310 | 420 | 460 | |
ECMO | FiO2 | – | – | 0.7 | 0.6 | 1 | 0.85 | 0.6 | 0.7 | 0.3 | – |
Sweep gas (L/min) | – | – | 8 | 5 | 3.5 | 3.5 | 2.5 | 3.5 | 3.5 | – | |
Pump flow (L/min) | – | – | 3 | 3 | 2.9 | 3 | 3.1 | 3.1 | 1.5 | – | |
Unfractionated heparin (units/h) | – | – | 0 | 260 | 340 | 340 | 250 | 750 | 800 | 500 | |
Atrial blood gas | pH | 7.138 | 6.88 | 7.345 | 7.368 | 7.447 | 7.494 | 7,424 | 7.465 | 7.419 | 7.372 |
PaCO2(mmHg) | 76.2 | 199.9 | 39.3 | 38.3 | 42.5 | 40 | 46.1 | 39.5 | 42.4 | 40.3 | |
PaO2(mmHg) | 92.8 | 129 | 73 | 86.3 | 44.7 | 83.5 | 83.5 | 76.9 | 67.8 | 86.9 | |
HCO3 −(mmol/L) | 25.2 | 37.3 | 21 | 21.5 | 28.7 | 27.5 | 29.5 | 27.8 | 26.8 | 22.9 | |
Lactate (mmol/L) | 4.5 | 4.13 | N/A | 8.57 | 2.27 | 1.83 | 1.56 | 1.3 | 1.04 | 0.78 | |
Coagulation | ACT (s) | – | – | 198 | 239 | 190 | 196 | 187 | 209 | 182 | 183 |
Water balance | Water balance (ml/day) | 4340 | – | – | 8840 | 2124 | 3583 | 1041 | −2410 | 184 | 1697 |