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Fig. 4 | JA Clinical Reports

Fig. 4

From: Effect of different surgical procedures on the accuracy of prediction of the plasma concentration of fentanyl: comparison between mastectomy and laparoscopic prostatectomy

Fig. 4

Difference in the predictive accuracy between mastectomy and laparoscopic prostatectomy. In mastectomy, the difference between the measured concentration of fentanyl and simulation-predicted concentration of fentanyl had no correlation with time from the first administration of fentanyl (r = 0.157, P < 0.01, y = 0.01x + 0.203). Approximately 0.3 ng/mL of a fixed bias was shown in all sampling stages (a). However, in the laparoscopic prostatectomy group, a fixed bias was influenced by sampling stage (b), and gradually became negative as the sampling stage increased. This finding implies that ≈0.3 ng/mL of a fixed bias in stage 1 decreased to −0.3 ng/mL in stage 4 systematically (r = −0.411, P < 0.01, y = −0.02x + 0.432)

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