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Table 3 Univariate association of preoperative and intra-operative variables with the ICU-free survival days

From: Lactate level during cardiopulmonary bypass as a predictor of postoperative outcomes in adult patients undergoing cardiac surgery

Variable

Regression coefficient [95% CI]

p value

Gender: male

−0.397 [−2.608 to 1.741]

0.692

Age

−0.028 [−0.191 to 0.055]

0.813

Body mass index

−0.216 [−0.426 to 0.0169]

0.069

Hypertension

0.738 [−1.463 to 3.181]

0.463

Diabetes

−0.114 [−3.083 to 2.749]

0.910

Dyslipidemia

−0.059 [−2.330 to 2.196]

0.953

Previous stroke

0.649 [−1.688 to 3.318]

0.518

Current smoking

−1.411 [−3.734 to 0.639]

0.163

Previous cardiac surgery

−0.415 [−4.173 to 2.736]

0.679

Chronic dialysis

1.940 [−1.279 to 14.99]

0.088

Preoperative eGFR

0.074 [0.036 to 0.111]

<0.001*

Preoperative BNP

−0.068 [−0.469 to 0.046]

0.568

Left ventricular ejection fraction

0.177 [−0.120 to 0.494]

0.137

Preoperative anticoagulant

−0.719 [−3.004 to 1.413]

0.475

Valve surgery

0.620 [−3.262 to 6.203]

0.537

CPB duration

−0.260 [−0.538 to −0.147]

0.028*

Aortic cross-clamping duration

−0.109 [−0.419 to 0.067]

0.361

Nadir hematocrit

0.179 [−0.061 to 0.321]

0.133

Mean CPB pressure

0.042 [−0.211 to 0.201]

0.727

Ratio of <CPB pressure 60 mmHg

−0.184 [−0.350 to 0.144]

0.123

Ratio of <CPB pressure 50 mmHg

−0.057 [−0.269 to 0.174]

0.636

Preoperative MAP—mean CPB pressure

−0.235 [−0.427 t6 0.172]

0.047*

Mean CPB flow index

−0.190 [−0.455 to 0.115]

0.110

Vasopressors during CPB

−0.134 [−2.487 to 2.175]

0.894

Transfusions during CPB with RBCs

1.800 [−0.332 to 5.195]

0.082

Lactate level at CPB-0 h

−0.094 [−0.298 to 0.070]

0.431

Lactate level at CPB-1 h

−2.120 [−4.566 to 0.327]

0.088

Lactate level at CPB-2 h

−2.646 [−4.455 to −0.837]

0.005*

  1. Data were shown as regression coefficients with 95% confidence intervals (CIs), ratio of <CPB pressure **mmHg (%): (duration of lower than **mmHg during CPB/total CPB time) × 100
  2. eGFR estimated glomerular filtration rate, BNP brain natriuretic peptide, CPB cardiopulmonary bypass, MAP mean arterial pressure, CPB-#h # h after CPB started
  3. *p < 0.05