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Table 1 Types of assays on rotational thromboelastometry

From: Therapeutic plasma exchange in heart transplantation: role of coagulation assessment with thromboelastometry

Test TF Contact Heparin effect Detectable condition(s) Hemostatic interventions
EXTEM +  a Extrinsic pathway, PLT count, fibrinolysis Plasma, PCC, or PLTs
FIBTEM +  a Fibrinogen levelb Cryo or fibrinogen conc.
APTEM +  a Systemic fibrinolysisc Antifibrinolytics
INTEM   + + Intrinsic pathway, PLT count, fibrinolysis Plasma, protamine, or PLTs
HEPTEM   + a Heparin effect Same as INTEM
  1. ACT activated clotting time, Cryo cryoprecipitate, Fibrinogen conc. fibrinogen concentrate, PCC prothrombin complex concentrate, PLT platelet, TF tissue factor activator, Contact contact activator (ellagic acid)
  2. aHeparin is neutralized by the reagent at concentrations up to 4–6 U/ml on EXTEM/FIBTEM/APTEM and 8 U/ml on HEPTEM
  3. bConfirmatory test for hypofibrinogenemia; low clot firmness (amplitude) on other ROTEM® tests may indicate either thrombocytopenia or hypofibrinogenemia
  4. cConfirmatory test for fibrinolysis; fibrinolysis may be shown on all the other ROTEM® tests