A case requiring tracheal stenting due to superior vena cava syndrome developing after craniotomy
© The Author(s) 2015
Received: 7 August 2015
Accepted: 2 November 2015
Published: 5 November 2015
We report a patient who developed sustained hypotension during craniotomy; further, owing to a mediastinal mass, critical tracheal stenosis and brain edema were observed after craniotomy, despite the absence of preoperative symptomatic superior vena cava (SVC) syndrome. A 62-year-old man underwent removal of a suspected metastatic brain tumor. The main brain tumor was speculated to be a metastatic tumor from lung cancer. A subsequent chest CT revealed a large solid tumor in the mediastinum. The maximum reduction in the cross-sectional area of the trachea was estimated to be 50 %. In addition, bilateral innominate veins were completely obstructed, and the superior vena cava was involved in the mass and was completely compressed. The patient did not show any cardiopulmonary symptoms or upper body edema. Intravenous lines were secured at the right extremity. General anesthesia was induced without any complications and was maintained with sevoflurane, remifentanil, and rocuronium. During the surgery, hemodynamic status fluctuated and was unstable. To maintain systolic blood pressure, continuous, massive infusion of noradrenaline was required. After the surgery, the patient was turned to the supine position. Massive facial edema was apparent. In addition, the bilateral upper extremities were significantly swollen. Despite the removal of the main lesion, brain edema was still observed on head CT. Chest CT revealed that the maximum reduction in the cross-sectional area of the trachea was estimated to be >90 %, which necessitated mechanical ventilation with tracheal intubation. On the day following craniotomy, tracheal stenting was performed uneventfully. The patient’s trachea was finally extubated, and his respiratory condition did not deteriorate. Although he did not develop SVC syndrome, the patient died from asphyxiation after coughing up blood at home 5 months after the procedure. It was suggested that fluid infusion from the upper extremities owing to the mediastinal tumor caused critical SVC syndrome.
KeywordsSuperior vena cava syndrome Mediastinal mass Tracheal stent
In case of impaired blood flow through the superior vena cava (SVC) to the right atrium due to external compression or intrinsic obstruction of the SVC, it is recommended that intravenous access should be secured in the lower rather than in the upper extremities for anesthesia management [1, 2]. However, to the best of our knowledge, there is no report available that describes such patients developing SVC syndrome perioperatively. We report a patient who developed sustained hypotension during craniotomy; further, owing to a mediastinal mass, critical tracheal stenosis and brain edema were observed after craniotomy, despite the absence of preoperative symptomatic SVC syndrome.
Peripheral 20-G and 22-G intravenous lines were secured at the right forearm and the right back of the hand. General anesthesia was induced with 100 mg of propofol plus 100 μg of fentanyl, and neuromuscular blockade was achieved with 50 mg of rocuronium. Manual ventilation with a mask was easily performed. Tracheal intubation with a 7.5 mm silicone reinforced tracheal tube was performed uneventfully. Before tube fixation, we confirmed that the distal tube end was positioned to avoid injury to the stenotic part of the trachea using a fiberoptic bronchoscope. General anesthesia was maintained with 1–1.5 % of sevoflurane, 0.05–0.1 μg/kg/min of remifentanil, and 10–15 mg/h of rocuronium. Transient hypotension was observed during induction of the anesthesia; however, it was treated using 8 mg of ephedrine. Craniotomy and removal of the brain tumor was performed in the left park-bench position. During the surgery, hemodynamic status fluctuated and was unstable, which became particularly apparent after an increase in urine output by mannitol administration. To maintain systolic blood pressure at 80–90 mmHg through the procedures, continuous, massive infusion of noradrenaline (0.05–0.07 μg/kg/min) was required. The operation time for the procedures was prolonged to 4 h and 25 min probably because of poor brain relaxation. Fluid balance including crystalloids and colloids infusion (5600 ml), blood products transfusion (560 ml), urine output (2650 ml), and blood loss (625 ml) was 2885 ml.
SVC syndrome results from impaired blood flow through SVC to the right atrium. Because the bilateral innominate veins were completely obstructed and SVC was involved in the mass and completely compressed in this case, SVC syndrome may have occurred at any moment preoperatively in this patient. However, the severity of the syndrome depends on the rapidity of the onset of obstruction and its location . When the obstruction is slowly progressive, collateral pathways develop and symptoms are usually mild or absent, as in this case . Therefore, we need to recognize that we underestimated his condition because he did not show clinical symptoms and signs of SVC syndrome.
Presuming that the respiratory and cardiovascular effects of his mediastinal tumor were not critical in the preoperative state, the reason why he developed SVC syndrome was unclear. It was an incident that would ultimately occur. Obviously, the primary cause of the rapid development of SVC syndrome was fluid infusion from an upper extremity. The fluid infusion from the upper extremity easily exceeded the drainage capacity of the collateral pathways, which increased venous pressure and promoted upper body edema. Simultaneously, the reduction of preload by mannitol-induced urination and afterload by anesthesia was not corrected by regular fluid infusion protocol using upper extremity fluid lines, which required further fluid infusion and administration of noradrenalin. This vicious circle exacerbated tracheal compression by the mediastinal tumor and brain edema. Therefore, intravenous lines in the upper extremities are contraindicated in cases with presence of SVC obstruction [1, 2] and such a patient can actually develop SVC syndrome with upper extremity fluid lines. We were overly optimistic about this case.
In conclusion, we presented a case of a mediastinal tumor developing critical SVC syndrome due to fluid infusion from the upper extremities.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. Institutional review board approval was also obtained (No.643). A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Superior vena cavaIntensive care unit
Intensive care unit
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